Shares of Eli Lilly (NYSE: LLY) fell sharply on Thursday, dropping more than 11% in regular trading after the company lowered its full-year 2025 profit outlook. The revised guidance overshadowed stronger-than-expected first-quarter results.

The pharmaceutical giant reported adjusted earnings per share of $3.34, topping analyst estimates of $3.25. Revenue jumped 45% year-over-year to $12.73 billion, also beating the $12.62 billion consensus, according to Visible Alpha.
The company’s strong revenue growth was primarily driven by its key diabetes and obesity drugs, Mounjaro and Zepbound. Mounjaro generated $3.84 billion in sales, more than double from a year ago and above the $3.76 billion estimate. Zepbound brought in $2.31 billion, up significantly from $517.4 million last year, but slightly below the $2.33 billion forecast.
Despite the strong earnings report, Eli Lilly has lowered its full-year profit guidance. The company expects 2025 EPS to range between $20.17 and $21.67, down from its prior guidance of $22.05 to $23.55. Adjusted EPS is now projected to range between $20.78 and $22.28, a reduction from the previous outlook of $22.50 to $24.00.
The drugmaker attributed the downward revision to “net losses on investments in equity securities” and acquired in-process research and development (IPR&D) charges, which totaled approximately $1.57 billion in the first quarter.
At the latest check, Eli Lilly (NYSE: LLY) shares were trading at $794.10, marking an 11.66% decline for the day. However, the stock remains up 2.86% year-to-date and has gained 7.72% over the past 12 months.
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